【摘 要】
:
Constitutive activation of STAT3 has been found in a wide variety of cancers, and it has been validated as an attractive anticancer therapeutic target.STAT3 SH2 domain inhibitors could compete with th
【机 构】
:
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009
【出 处】
:
中国化学会第十届全国天然有机化学学术会议
论文部分内容阅读
Constitutive activation of STAT3 has been found in a wide variety of cancers, and it has been validated as an attractive anticancer therapeutic target.STAT3 SH2 domain inhibitors could compete with the native phosphotyrosine (pTyr) peptide to block both STAT3 activation and dimerization.
其他文献
Andrographolide sodium bisulphite (ASB), widely used in China for the treatment of bacterial infections, is a water-soluble sulfonated derivative of andrographolide, an important diterpenoid lactone i
Dianthus chinensis (Caryophyllaceae) is a small herb widely distributed in the northeast of China and its aerial parts, known asQumai, has been cited as a traditional Chinese medicine in Chinese Pharm
OBJECTIVE To study the chemical constituents of 95% EtOH extract of Mappianthus iodoides Hand.-Mazz..METHODS Various chromatographic techniques were used to separate and purify the constituents.The sp
Hirsutane型倍半萜,以线性三并五元环为基本骨架,结构独特.自1967年Comer FW报道第一个hirsutane型倍半萜hirsutic acid C,至今已发现了arthrosporol、 arthrosporone、 chloriolin A、 chloriolin B、 chlorostereone、 complicatic acid、 connatusin A、 connatus
Scutellarin is an active constituent extracted from traditional Chinese medicine Erigeron breviscapus (vant) Hand-Mazz1, which has been used for the treatment of cerebral infarction,coronary heart dis
Agents that can enhance tumor cell apoptosis have potential for the treatment of cancer.Herein,we report the identification of bigelovii A, a noroleanane-type pentacyclic triterpenoid from Salicornia
A convenient and one-pot synthesis of 2-arylbenzofuran-3-carboxylic acids from (E)-2-(2-bromo-phenyl)-3-phenylacrylic acids via Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetheri
Three new ent-pimarane diterpenes, named dumetorumanes A-C (1-3), were isolated from the ethanol extract of Aralia dumetorum, together with three known compounds including ent-pimara-8(14), 15-diene-1
In many reports, triterpenoids have been studied and described as anti-inflammatory and immunomodulatory agents.2α-Hydroxy-3β-acetoxy-lup-20(29)-en-28-oic acid (LUP), a lupane-type triterpenoid, was i
Macranthoside B (MB), a saponin from Lonicera macranthoides, can block cell proliferation and induce cell death in several types of cancer cells, while the precise mechanisms by which MB exerts antica