【摘 要】
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Objective Chemotherapy is one of most important treatment for human cancers.However, its side effects such as intestine dysfunction significantly impaired its clinical efficacy.This study was designed
【机 构】
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Zhejiang Traditional Chinese Medical University, 548 Binwen Road, Hangzhou 310053, Zhejiang Province
【出 处】
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2013中国医师协会中西医结合医师大会
论文部分内容阅读
Objective Chemotherapy is one of most important treatment for human cancers.However, its side effects such as intestine dysfunction significantly impaired its clinical efficacy.This study was designed to investigate the protective effect of curcumin on chemotherapy-induced intestinal dysfunction in rats.Methods Sixty healthy Wistar rats were randomly divided into control group (normal saline), 5-FU group and 5-FU+curcumin group.The weight, endotoxin, DAO and D-lactate level were determined during the experiment.The pathological change of intestinal mucosa structure was studied under light microscopy and electron microscopy.The expression of Bax, Bcl-2 and Caspase-3 were assessed by immunohistochemical staining.Results The curcumin intragastrically administrated obviously reduced 5-FU-induced weight-loss.5-FU induced dramatic increase of serum endotoxin, D-lactate and D-AminoAcid Oxidase (DAO) that were significantly reversed by curcumin treatment.Meanwhile, 5-FU-induceddamage to intestinal mucosa structure was markedly recovered by curcumin.The expression of Bax and Caspase-3 were dramatically increased after 5-FU treatment (p<0.01) and curcumin treatment significantly reduced Bax expression (p<0.05) but had only a moderate effect on reducing caspase-3 expression (p>0.05).Interestingly, Bcl-2 expression was low in control group but increased after 5-FU treatment (p>0.05) and curcumin treatment further stimulated Bcl-2 expression (p<0.05).Conclusions Curcumin can significantly reverse chemotherapy-induced weight-loss, increase of serum endotoxin, D-lactate and DAO and damage to intestinal mucosa structure.Curcumin also reduced the expression of pro-apoptotic Bax but stimulated anti-apoptotic Bcl-2 to attenuate 5-FU-induced apoptosis of intestinal epithelial cells.The clinical administration of curcumin may improve chemotherapy-induced intestinal dysfunction, thus increasing the clinical efficacy of chemotherapy.
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