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  5. Metabolome alteration of maternal-fetal unit biofluid in IUGR rats induced by prenatal caffeine inge

Metabolome alteration of maternal-fetal unit biofluid in IUGR rats induced by prenatal caffeine inge

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：lsh01015
【摘 要】
：
Aim: Metabolic abnormalities were reported in maternal-fetal unit with intrauterine growth retardation (IUGR).Here we aimed to investigate the metabolomes in maternal-fetal biofluid of caffeine-induce
【作 者】
：
Hao KOU Hui WANG 
【机 构】
：
Department of Pharmacology, School of Basic Medical Science,Wuhan University,Wuhan 430071, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
caffeine IUGR metabolome glucocorticoid biomarkers 
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Aim: Metabolic abnormalities were reported in maternal-fetal unit with intrauterine growth retardation (IUGR).Here we aimed to investigate the metabolomes in maternal-fetal biofluid of caffeine-induced IUGR and tried to explore maternal biomarkers.Methods: Pregnant rats were orally treated with caffeine (20, 60, and 180 mg/kg) from gestational days (GD) 11 to 20.Metabolome of maternal and fetal plasma on GD20 and maternal plasma on different times (GD11, GD14, and GD17) were analyzed by 1H nuclear magnetic resonance-based metabonomics.
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