• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both pa

Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both pa

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：shmilygang8751
【摘 要】
：
Aim: Blood brain barrier (BBB) dysfunction is a common facet of cerebral ischemia, and the alteration of drug transporter, P-glycoprotein (P-gp), has been documented.This study explores influence of d
【作 者】
：
Wei-rong FANG Peng LV Xiao-han GENG Er-xin SHANG Qi-chuan YANG Lan SHA Yun-man LI 
【机 构】
：
Department of Physiology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
cerebral ischemia blood brain barrier P-glycoprotein verapamil 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: Blood brain barrier (BBB) dysfunction is a common facet of cerebral ischemia, and the alteration of drug transporter, P-glycoprotein (P-gp), has been documented.This study explores influence of damaged BBB and elevated P-gp on cerebral verapamil penetration after ischemia both in vivo and in vitro.
其他文献
L-type Ca2+ channel mediates orexin-A-induced AMPK activation in hypothalamic ARC neurons
Aim: Orexin-A, a neuropeptide secreted by the neurons in lateral hypothalamic area (LHA), is one of the key factors for the regulation of feeding behavior.Here, we investigated the involvement of calc
会议
orexin-AL-type calcium channelAMPKneurpeptide Yfood intake
Xanthotoxol suppresses the inflammatory response and protects against ischemic brain injury followin
Aim: Our previous study has demonstrated that xanthotoxol possesses neuroprotective properties following transient focal cerebral ischemia.The present study was designed to investigate the effect of x
会议
xanthotoxolpermanent focal cerebral ischemiainflammatory response
Effects of xanthoceraside on memory impairments and central cholinergic system in rats by lesions of
Aim: The present study is to investigate the effect and mechanisms of xanthoceraside on memory impairments and central cholinergic system in Alzheimers disease (AD) rat model conducted by lesions of b
会议
xanthocerasideAlzheimer's diseaselearning and memoryMeynert's basal
Determination of lapachol by liquid chromatographic-mass spectrometry and the application to pharmac
Aim: To study the quantification methods and pharmacokinetic application of lapachol.Methods: A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry method (LC/ESI/MS
会议
lapacholdeterminationpharmacokineticsLC-ESI-MSn
Telomere-independent Rap1, modulates NF-κB-dependent inflammation in macrophages
Aim: The activity of nuclear factor (NF-κB) is modulated by cytoplasmic repressor activator protein 1 (Rap1) in cancel cells.Experiments were designed to test whether or not Rap1 is present in atherom
会议
Rap1NF-κBmacrophageinflammationatherosclerosis
Aquaporin-1 dependent proximal tubular cells migration mediates reno-protective effect of acetazolam
Aim: The study is to investigate whether diuretic acetazolamide (AZA) protects against renal ischemia-reperfusion (I/R) injury, and its possible link with water channel aquaporin-1 (AQP1).Methods: In
会议
Aquaporin-1 (AQP1)ischemia-reperfusionacute kidney injuryacetazolamidemigrat
WS070117 ameliorates the formation of foam cells by regulating the expression of LOX-1 and ABCG1 in
Aim: The present study investigated the effects of WS070117, a novel small molecule compound, on foam cell formation, and the possible underlying mechanism.Methods: J774.A1 murine macrophages were pre
会议
WS070117foam cellsLOX-1ABCG1AMPK
Thymoquinone causes endothelium-dependent augmentation depending on activation of soluble guanylyl c
Aim: Experiments were designed to determine the effects of thymoquinone, an alkaloid with vasodilator properties, in coronary arteries.Methods: Rings, with or without endothelium, of porcine coronary
会议
8-Bromo cyclic GMPdeta NONOatehypoxianitric oxideprostaglandin F2α
4-HNE increases intracellular ADMA levels in cultured HUVECs through miR-21-dependent mechanisms
Aim: To investigate whether 4-hydroxynonenal (4-HNE) regulates asymmetric dimethylarginine (ADMA) metabolism through affecting the expression of ADMA metabolizing enzymes and the involvement of microR
会议
microRNA 21 (miR-21)dimethylarginine dimethylaminohydrases (DDAH)asymmetric di
Therapeutic effects of ginsenoside metabolite compound K in adjuvant-induced arthritis via attenuati
Aim: An in vitro study has shown joint-protective effects of ginsenoside metabolite compound K (CK) in RA, but the effects of CK in RA animal model and the mechanisms are still unknown.In this study,
会议
ginsenoside metabolite compound Kdendritic cellsadjuvant-induced arthritisimm