Blood based diagnosis of Alzheimer’s disease (AD) by detecting Amyloid-beta Molecule

• 作 者: YoungSooKim;KyoSeonHwang;JiYoonKang;SungMinKang;TaeSongKim;
• 机 构: Brain Science Institute,Korea Institute of Science and Technology(KIST),Seoul 136-791,Korea
• 出 处: 第九届全国微全分析系统学术会议、第四届全国微纳尺度生物分离分析学术会议、2014国际微流控芯片与微纳尺度生物分离分析学术
• 发表日期: 2014年期

　　Alzheimers disease(AD)is a progressive neurodegenerative disorder that is characterized by the conformational transition of amyloid-β(Aβ)into soluble oligomers,protofibrils and fibrils,which accumulate to form insoluble plaques during the abnormal aggregation process.Interestingly,Aβ is one of a few neuropathological hallmarks with blood-brain barrier permeability,via two transporters,lipoprotein receptor-related protein(LRP-1)and receptor for advanced glycation end products(RAGE).