Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fert

来源 :2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议 | 被引量 : 0次 | 上传用户：tanleilei

【摘要】

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【作者】

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Yunqiang Liu Dachang Tao Yongjie Lu Yuan Yang Yongxin Ma Sizhong Zhang

【机构】

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Department of Medical Genetics and Division of Human Morbid Genomics,State Key Laboratory of Biother

【出处】

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2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议

【发表日期】

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2014年3期

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The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome, and the tail of spermatozoa.To investigate the role of Znf230 in spermatogenesis, we generated Znf230-deficient mice by disrupting Znf230 exon-5 and exon-6 using homologous recombination.The homozygous Znf230-knockout (KO) mice did not exhibit Znf230 mRNA expression and Znf230 protein production.Znf230 KO mice exhibited no obvious impairment in body growth or fertility.

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