【摘 要】
：
Recurrent genome copy number aberrations are known to be a common feature of many cancers,including Hepatocellular carcinoma (HCC), and their analysis is expected to reveal genes involved in carcinoge
【机 构】
：
第二军医大学基础部医学遗传学教研室,上海200433
【出 处】
：
2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议
论文部分内容阅读
Recurrent genome copy number aberrations are known to be a common feature of many cancers,including Hepatocellular carcinoma (HCC), and their analysis is expected to reveal genes involved in carcinogenesis.However, in many regions with high frequency copy number variations (CNVs), the aberrantly expressed protein-coding genes is unable to make a sense,which suggest that the mechanisms underlying carcinogenesis may be partly contributed to the differently expression of long non-coding RNA (lncRNAs).Then an overlap analysis of lncRNAs expression microarray and genome copy number variations data in HCC was carried out and we identified a set of lncRNAs whose expression levels correlated with common chromosomal aberrations, in which lncRNA-PRAL is consistently decreased with a significant correlation with the copy number variations.We found that lncRNA-PRAL could promote the tumor cell apoptosis and suppress the progress of carcinogenesis in vivo.Moreover,lncRNA-PRAL can participate in HSP90-p53 protein complex formation to help facilitate the nuclear transportation of p53.
其他文献
Background: Toxoplasma gondii is a protozoan parasite that infects almost all species of animals and resulted in toxoplasmosis, a condition which includes encephalitis in immunocompromised individuals
Background: Congenital heart disease (CHD) is the most common birth defects, which is the top one defect in China.But the genetic etiology of sporadic CHD remains poorly understood.Methods: In our stu
Objective: To evaluated survival motor neuron 2 (SMN2) and neuronal apoptosis inhibitory protein (NAIP) gene copy distribution and the association of copy number with survival in 232Chinese spinal mus
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked incompletely dominant enzyme deficiency that results from G6PD gene mutations.Women heterozygous for G6PD mutations exhibit variation
Piwi-like2 (piwil2)基因在肿瘤中广泛表达,具有抵抗外界刺激介导的细胞凋亡的功能.但迄今为止对Piwil2在Fas介导的凋亡过程中的作用尚不清楚.我们的研究首次证实Piwil2能抑制Fas介导的凋亡进程.通过细菌双杂交筛选,我们鉴定出一个新的Piwil2作用蛋白Keratin8 (K8).研究结果显示,Piwi12能通过其PIWI结构域与K8和p38形成蛋白复合物,进而增加K8 S
KLF 1 regulates erythroid lineage commitment, globin switching, and the terminal maturation of red blood cells.Variants in human KLF1 are identified as an important causative factor that produces a wi
Mutations in human Krǖppel-like factor 1 (KLF1) have recently been reported to be responsible for increased fetal hemoglobin (HbF) and hemoglobin A2 (HbA2).As increased HbF and HbA2 levels are importa
Phenotypic variations in α-thalassemia mainly depend on the defective α-globin gene number.Genetic modifiers of the phenotype of Hemoglobin H (HbH) disease were poorly reported, apart from β-thalassem
目的:观察翻百草丹参合剂干预治疗2型糖尿病大鼠模型糖、脂代谢和PPAR-γ基因表达水平的分子机制研究.方法:建立2型糖尿病大鼠模型,将90只大鼠随机分为4组,正常对照组15只,T2DM模型组25只,马来酸罗格列酮阳性对照组25只,翻白草丹参合剂(翻白草、丹参、黄芪、五味子、天花粉)中药实验组25只.翻白草丹参合剂采用水萃取方法制备药物制剂,马来酸罗格列酮水溶剂,中药实验组和阳性对照组每日早晚两次灌
Many protein-coding oncofetal genes are highly expressed in murine and human fetal liver and silenced in adult liver.The protein products of these hepatic oncofetal genes have been used as clinical ma