Molecular characterization, tissue distribution, and immune reaction expression of karyopherins in A

• 作 者: LiJun;PengShuying;
• 机 构: College of life science, Huaibei normal university, Anhui, Huaibei, 235000
• 出 处: 第九次全国动物生物技术学术研讨会
• 发表日期: 2015年期

　　Karyopherins also called Importins, including alpha-and beta-type, are important transport proteins in eukaryotic cells that carry cargoes across nuclear pore complexes into or out of nucleus.Karyopherin alphas (KPNAs) cannot carry cargoes across nuclear pore complexes (NPCs) by themselves but they can act as receptors attaching cargoes to Karyopherin beta 1 (KPNB 1) and forming trimers which can across NPCs and finally release cargoes in nucleoplasm.Karyopherin betas (KPNBs) include Importin betas, Exportins and Transportins.Importin betas transport cargoes into nucleus and only Karyopherin beta 1 (KPNB 1) can recognize KPNAs to form complexes.Exportins transport cargoes out nucleus while transportins transport cargoes either into or out nucleus.