Physiological roles of autophagy during development: Functional analysis of "ubiquitin-like&quo

来源 :The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会 | 被引量 : 0次 | 上传用户：pluto529

【摘要】

：

　　The diversity of physiological processes associated to autophagy, such as cellular homeostasis,survival, differentiation, development and immunity led to th

【作者】

：

RenaudLegouis;CélineJenzer;ChristopheLefebvre;EmmanuelCuletto;ElenaSimionato;CélineLargeau;MarionManil-Segalen;

【机构】

：

Institute for Integrative Biology of the Cell, CEA, CNRS, Université Paris Sud, 1 avenue de la terra

【出处】

：

The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会

【发表日期】

：

2015年期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The diversity of physiological processes associated to autophagy, such as cellular homeostasis,survival, differentiation, development and immunity led to the emergence of several animal models among which the nematode C.elegans.Our group aims to understand the particular roles for selective autophagy during developmental processes.The formation of the autophagosomes requires the recruitment of ubiquitin-like proteins to their membrane.The yeast ubiquitin-like Atg8 is highly conserved but presents several homologs in mammals, split into the LC3 and the GABARAP families.C.elegans only possesses one GABARAP and one LC3 homolog named LGG-1 and LGG-2, respectively.

其他文献

DRAM1 protect against rotenone-induced dopaminergic damage

　　Many neurodegenerative diseases are characterized by abnormal accumulations of insoluble protein aggregates, such as Amyloid beta oligomers in Alzheimer's d

会议

Stress-Responsive MAPK Family Members, MK2/MK3, Activate Starvation-Induced Autophagy through Beclin

　　Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by a set of evolutionarily conserved gene products, the autophagy (ATG) p

会议

The last three amino acids of ATG13 control binding to ULK1/2

　　(Macro-)Autophagy describes a process responsible for the degradation of intracellular proteins and organelles.In recent years, the ULK1/2 complex comprisin

会议

A kinase feedback loop controls RAS-driven, autophagy-dependent cancers

　　Activating mutations in the RAS oncogene are common in cancer but are difficult to therapeutically target.RAS activation promotes autophagy, a highly regula

会议

Atg20 and Atg24 family proteins are important for organelle autophagy in fission yeast

　　During starvation, autophagy degrades cytoplasmic constituents including organelles such as ER and mitochondria.It remains unclear to what extent and how or

会议

Atg20 and Atg24 familyER-phagymitophagyPX-BARmulti-oligomers

The tissue-, time-and substrate-specific requirement forlgg-1 and Igg-2 in the autophagy pathway

The presence of multiple homologs of the same Atg gene in multicellular organisms confers a layer of complexity on the more elaborate autophagic machinery.Howev

会议

Overexpression Atg1 rescues pink1/parkin muscle degeneration by promoting mitochondrial fission Dros

　　Mitochondria dysfunction is considered as a hallmark of multiple neurodegenerative diseases,such as Parkinson's disease (PD).Mutations in two PD related gen

会议

Regulation of selective autophagy by nuclear shuttling of ALFY

The autophagy-linked FYVE protein (ALFY) is a large multi-domain protein implicated in the selective degradation of ubiquitinated protein aggregates by autophag

会议

Opposing roles of autophagy and the tumor suppressor UVRAG in Drosophila intestinal stem cells

Stem cells are critical for the maintenance of adult tissues and organs, including the intestinal tract of mammals and Drosophila.We find that intestinal stem c

会议

Human diseases associated with selective autophagy pathways

会议

Physiological roles of autophagy during development: Functional analysis of "ubiquitin-like&quo

其他学术论文