【摘 要】
：
Objective: Fructose-1,6-bisp hosphatase(FBP1)is often known as a rate-limiting enzyme in gluconeogenesis.Recently,its catalytic activity-independent function,repress hypoxia induced factor(HIF)in the
【机 构】
：
Peking University First Hospital,Beijing 100034,China
【出 处】
：
华夏医学论坛·泌尿生殖2015暨亚太性医学年会2015
论文部分内容阅读
Objective: Fructose-1,6-bisp hosphatase(FBP1)is often known as a rate-limiting enzyme in gluconeogenesis.Recently,its catalytic activity-independent function,repress hypoxia induced factor(HIF)in the nucleus,was identified.The aim of this study was to investigate the relationship between FBP1 and hypoxia related genes expression in clear cell renal cell carcinoma(ccRCC).Methods: The expression levels of FBP1,HIF-1α,HIF2α,erythropoietin(Epo)and carbonic anhydrase Ⅸ(CA9)were assessed by immunochemical staining in archival ccRCC paraffin blocks from 123 patients using the tissue microarray technique.The expression level of FBP1 was then correlated with clinicopathological factors and the expression levels ofHIF-1α,HIF-2α,Epo and CA9.Results: Clinicopathological factors including age,gender,TNM stage and Fuhrman grade were indifferent between the patients with low FBP1 expression and those with strong FBP1 expression in ccRCC.FBP1 expression level was positively correlated with the expression levels of HIF1α(P=0.005)and Epo(P=0.010),but without correlation with the expression level of HIF-2α(P=0.123)and CA9(P=0.513)in ccRCC tissues.Conclusions: Our findings may be useful for recognizing the association between FBP1 and hypoxia related genes expression and understanding the mechanisms of ccRCC tumorigenesis.
其他文献
Objective: To evaluate the feasibility and safety of pure laparoscopic radical nephrectomy and thrombectomy for renal tumor patients with venous tumor thrombus.Methods: From Jan 2013 to Dec 2014,recor
Objective: Bladder cancer is the most common malignancy of urinary system in China.Radical cystectomy with bilateral pelvic lymph node dissection is indicated for highrisk non-muscle invasive bladder
Objective: To evaluate the association between tumor squamous and/or glandular differentiation and tumor biological characteristics,to validate the impact of these histologic variants on oncologic out
Objective: To evaluate the clinical safety and efficacy of kidney-sparing surgery to treat the primary transitional cell carcinoma of ureter.Methods: The materials of 29 cases which underwent kidneysp
To study the erectile changes of abnormal balgam syndrome with impotence rats model and the gonad axial mechanism.The study selected 70 normal mature male SD rats,10 of them were randomly chosen as th
Background and purpose: Retroperitoneal laparoscopic nephroureterectomy(LNU)is a classic technique for the treatment of patients with urothelial cancer of the upper urinary tract.Management of the dis
Background: There is no consensus regarding whether androgen deprivation therapy(ADT)is associated with cardiovascular disease(CVD)and cardiovascular mortality(CVM).The objective of this study was to
Objective: To investigate the therapeutic effects and potential mechanisms of icariside Ⅱ(ICA Ⅱ)on improving diabetic nephropathy(DN)in streptozotocin(STZ)induced type Ⅰ diabetic rats.Methods: Newborn
Objective: Dysfunction of human cavernous endothelial cells(HCECs)is a common pathological alteration caused by elevated high blood glucose levels associated with diabetes.To explore the protective ef
Objective: Self-renewal and differentiation of endogenous stem cells(SCs)are essential for adult tissue homoeostasis and intrinsic healing capacity.In this study,we hypothesize that penis contains a s