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Objective: Bladder cancer is the most common malignancy of urinary system in China.Radical cystectomy with bilateral pelvic lymph node dissection is indicated for highrisk non-muscle invasive bladder cancer after BCG failure.But data regarding early cystectomy before BCG failure is lacking.We aimed to investigate the overall survival and disease-specific survival and related influence factors in patients undergoing radical cystectomy for pathological non-muscle invasive bladder cancer without prior BCG therapy.Methods: From Jan 2006 to Dec 2012,a total of 524 patients underwent radical cystectomy in Peking University 1st Hospital.Selection criteria as below:(Ⅰ)pathological stage Ta,T1 or Tis;(Ⅱ)urothelial carcinoma on pathological diagnosis;(Ⅲ)no neoadjuvant chemotherapy or radiotherapy before operation;(Ⅳ)no intra-vesical BCG treatment before radical eystectomy.A total of 164 patients were included in this study.Clinical data were retrospectively collected.Results: Of all the patients included,159 had T1 disease,5 had CIS only,and no Ta patient was included.Lymph node metastasis was noted in 6 patients.All of the 6 patients were in T1 stage.Of all the patients,136 underwent standard bilateral lymph node dissection,5 underwent extended lymph node dissection,while 23 didnt have any LND.The 5-year OS and disease-specific survival for all the patients was 85%and 91%,respectively.The 5-year OS and disease-specific survival for patients undertaken lymph node dissection was 89%and 95%.The 5-year OS and disease-specific survival for patients didnt undertake lymph node dissection was 66%and 73%.There was a significant difference both on OS(P=0.012)and DFS(P=0.011)between patients with or without LND.Presence of lymph node metastasis was associated with a decreased survival(P=0.060).Recurrence occurred in 18 patients.And patients with recurrence harbored a significant poorer survival(P<0.001).No significant statistical difference was found on different tumor grade(P=0.931).No other related influence factors were noted.Conclusions: Patients with pathological non-muscle invasive bladder cancer underwent early radical cystectomy had a favorable prognosis,bilateral pelvic lymph node dissection is essential for this procedure as it gains a survival benefit for the patients.