【摘 要】
：
Autophagy is a highly conserved cellular process for degradation of bulk cytoplasmic materials for maintenance of cellular homeostasis and in response to starva
【机 构】
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DepartmentofCancerBiology,UniversityofCincinnatiCollegeofMedicine
【出 处】
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The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
论文部分内容阅读
Autophagy is a highly conserved cellular process for degradation of bulk cytoplasmic materials for maintenance of cellular homeostasis and in response to starvation.Autophagy dysfunction is implicated in a variety of diseases including cancer.Due to its impact on many cellular functions, autophagy has been shown to play both tumor suppressive and tumor promoting functions in different contexts and models.FIP200 (FAK-family Interacting Protein of 200 kDa)was initially identified in my laboratory in 2000 and subsequently shown to be a component of the ULK1/Atg13/FIP200 complex essential for the induction of autophagy.Recent studies by Dr.Guans group showed ablation of FIP200 results in a progressive loss of neural stem cells (NSCs) pool and impairment in neuronal differentiation specifically in the postnatal brain, but not the embryonic brain.They further showed that defect in maintaining the postnatal NSC pool was caused by p53-dependent apoptotic responses and cell cycle arrest.However, the impaired neuronal differentiation was rescued by anti-oxidant NAC treatment, but not by p53 inactivation.In this presentation, Dr.Guan will discuss their latest studies on the analysis of the role of FIP200 and other autophagy genes in the regulation of neural stem cells.
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