Cab39/AMPK/mTOR pathway mediates p53-independent erythroid apoptosis in miR-144/451-/-mice upon stre

来源 :The 2nd International Symposium on Erythrocyte Biology(2016第 | 被引量 : 0次 | 上传用户：maidouqaz

【摘要】

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【作者】

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Xiao Fang Yaying Hou Fan Hu Duonan Yu

【机构】

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Noncoding RNA Research Center, Yangzhou University, Yangzhou, PR China 225002

【出处】

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The 2nd International Symposium on Erythrocyte Biology(2016第

【发表日期】

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2016年10期

【关键词】

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MiR-144/451 erythropoiesis apoptosis Cab39/AMPK/mTOR signaling

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　　Abnormal regulation of small noncoding RNAs,or microRNAs (miRs) has been implicated in the pathophysiology of various human diseases,such as cancer,cardiovascular disease and anemia.miR-144 and-451,which are encoded by a bicistronic miRNA locus,have been observed to be strongly elevated during erythroid maturation.

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Cab39/AMPK/mTOR pathway mediates p53-independent erythroid apoptosis in miR-144/451-/-mice upon stre

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