Deficiency of TET2 led to expansion of dysfunctional erythroid progenitors

来源 :The 2nd International Symposium on Erythrocyte Biology(2016第 | 被引量 : 0次 | 上传用户：chrisl0708

【摘要】

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【作者】

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Xiaoli Qu Lixiang Chen Jie Li John Hale Yuming Huang Yaomei Wang Julien Papoin Xinhua Guo Narla Mohandas Qiaozhen Kang Xiuli An

【机构】

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School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R.China;Laboratory of Memb

【出处】

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The 2nd International Symposium on Erythrocyte Biology(2016第

【发表日期】

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2016年10期

【关键词】

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Erythropoiesis MDS TET2 CFU-E cell proliferation apoptosis

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　　Erythrocyte development is a complex process which contains erythroid progenitors burst-forming unit-erythroid (BFU-E),colony-forming unit-erythroid (CFU-E) and erythroid precursors proerythroblast,basophilic erythroblast,polychromatic erythroblast,orthochromatic erythroblast in the bone marrow.

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Deficiency of TET2 led to expansion of dysfunctional erythroid progenitors

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