PATHOGEN INACTIVATION OF BLOOD COMPONENTS TO PREVENT TRANSFUSION TRANSMITTED INFECTIONS: EFFECTS ON

来源 :The 2nd International Symposium on Erythrocyte Biology(2016第 | 被引量 : 0次 | 上传用户：xxm181512619

【摘要】

：

【作者】

：

Laurence Corash

【机构】

：

Laboratory Medicine, University of California School of Medicine, San Francisco, CA 94143 Clinical R

【出处】

：

The 2nd International Symposium on Erythrocyte Biology(2016第

【发表日期】

：

2016年10期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Transfusion of red blood cells (RBCs) is a critical supportive therapy for healthcare.Experience over the past 50 years has shown that infectious pathogens can enter the blood donor population undetected,and be transmitted by transfusion resulting in risk of transfusion-transmitted infections (TTI) with devastating health effects for patients.

其他文献

Calcium Signaling Involvement in Cadmium-Induced Astrocyte Cytotoxicity and Cell Death through Activ

会议

Aberrant DNA binding by mutant (E339D) KLF1 induces upregulation of embryonic-globin in adult mice

The KLF1 transcription factor regulates nearly all aspects of erythroid differentiation including heme synthesis and globin regulation.Previously,in collaborative studies with Dr.James Bieker (New Yor

会议

Induction of γ-Globin Gene Expression via Direct Delivery of Synthetic Zinc Finger DNA-Binding Domai

Reactivation of γ-globin expression has been shown to ameliorate disease phenotypes associated with mutations in the adult β-globin gene,including sickle cell disease.Previous studies have shown that

会议

Pomalidomide reverses gamma-globin silencing during human erythropoiesis through the transcriptional

Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin.Pomalidomide,a third-generation immunomodulatory drug,was proposed to induce fetal hemoglobin productio

会议

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expr

Iron overload results in significant morbidity and mortality in β-thalassemic patients.Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepc

会议

β-thalassemiairon overloadhepcidinBMP-Smad signaling

Modeling too much or too little erythropoiesis in mouse disease models

Erythropoietin (Epo) plays a critical role in the regulation of red cell mass (RCM) according to tissue oxygen levels.Hypoxia inducible factor-2 (HIF-2) is known to be a master regulator for Epo expre

会议

Chromatin signaling in transcription and erythropoiesis

The modulation of chromatin structure is a key step in transcription regulation in mammalian cells that eventually determines lineage commitment and differentiation,but the epigenetic regulators that

会议

Translational Hematology: the role of ribosomes in bone marrow failure

More than a decade has passed since the initial identification of ribosomal protein gene mutations in patients with Diamond-Blackfan anemia (DBA),a hematologic disorder that became the founding member

会议

The Critical role of plekstrin-2 in the pathogenesis of JAKV617F-induced myeloproliferative neoplasm

V617F driver mutation of JAK2 is the leading cause of Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs).Studies on the pathogenesis of JAK2V617F positive MPNs have primarily focused

会议

Mutation of a GATA1 binding site in ALAS2 intron 1 arrests erythroid development in vivo

ALAS2 encodes δ-aminolevulinate synthase,which catalyzes the rate-limiting step of heme biosynthesis in erythroid cells.ALAS2 mutations are responsible for X-linked sideroblastic anemia (XLSA),which m

会议

GATA1XLSAALAS2erythroid developmentintronic mutation

PATHOGEN INACTIVATION OF BLOOD COMPONENTS TO PREVENT TRANSFUSION TRANSMITTED INFECTIONS: EFFECTS ON

其他学术论文