Rational Design of a Live Attenuated Dengue Vaccine: 2'-O-Methyltransferase Mutants Are Highly

• 作 者: RolandZu(")st[1]Yong-QiangDeng[2]BrettR.Ellis[3]EstherM.Ellis[3]MichaelPoidinger[1]FrancescaZolezzi[1]Cheng-FengQin[2]Pei-YongShi[4]KatjaFink[1]Hong-PingDong[5]Xiao-FengLi[2]DavidC.Chang[5]BoZhang[6]
• 机 构: Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
• 出 处: 第十届全国病毒学学术研讨会
• 发表日期: 2013年期

　　Dengue virus is transmitted by Aedes mosquitoes and infects at least 100 million people every year.Progressive urbanization in Asia and South-Central America and the geographic expansion of Aedes mosquito habitats have accelerated the global spread of dengue, resulting in a continuously increasing number of eases.A cost-effective, safe vaccine conferring protection with ideally a single injection could stop dengue transmission.