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The electrostatic interaction serves as an ideal way to delivery charged anticancer drugs shows several advantages against traditional physical entrapment: 1)Highly drug loading capacity; 2)The stability and the drug is not easy to leak out; 3)Enhancing drug bioavailability while reducing severe side effects; 4)Especially susceptible to environmental acidity,which allows the development of pH-sensitive drug delivery systems.We synthesis of L1 to delivery charged anticancer drug DOX through electrostatic interaction and it can cross-link in this context of the thiol–acrylate Michael addition reaction to produce a β-thiopropionate linker,which can be hydrolyzed selectively under mild acidic conditions,thus leading the stimulate release of DOX under tumor environment.Its high drug loading content,stability,the stimulate release at tumor environment and remarkable anticancer activity may have an potential application in drug delivery and bioimaging.