【摘 要】
：
Chemotherapy is a primary treatment for metastatic cancer,but its efficacy is often limited by the adverse effects of cytotoxic drugs.Targeted cancer treatment may reduce the non-specific toxicity of
【机 构】
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Chinease Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Chemotherapy is a primary treatment for metastatic cancer,but its efficacy is often limited by the adverse effects of cytotoxic drugs.Targeted cancer treatment may reduce the non-specific toxicity of chemotherapy by selectively directing the firepower to tumor cells.MUC1 protein is an attractive target for tumor-specific therapy,because it is overexpressed in most adenocarcinomas,including breast,lung,colon,stomach,pancreatic and prostate cancers.Using aptamers that could bind to MUC1,we explored several novel strategies for targeted therapy against adenocarcinoma.First,we developed an 86-base DNA aptamer(MA3)that bound to MUC1 structure with a Kd of 38.3 nM.Using A549 lung cancer and MCF-7 breast cancer cells as MUC1-expressing models,MA3 was found to preferentially bind to the MUC1-positive but not the MUC1-negative cells.
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