【摘 要】
：
本综述着重介绍灵芝,这种真菌类担子菌种草本药物在免疫调节方面的最新研究进展.常见的灵芝种类有赤芝,松杉灵芝,薄盖树芝和平盖灵芝.从灵芝中可以提取到几种有较强免疫调节
【出 处】
：
华东六省一市生物化学与分子生物学会2015年学术交流会
论文部分内容阅读
本综述着重介绍灵芝,这种真菌类担子菌种草本药物在免疫调节方面的最新研究进展.常见的灵芝种类有赤芝,松杉灵芝,薄盖树芝和平盖灵芝.从灵芝中可以提取到几种有较强免疫调节作用的物质,包括多糖(主要是β-D-葡聚糖),蛋白质(如灵芝-8)及三萜类,其主要作用包括:调节免疫效应细胞(如T细胞,巨噬细胞和自然杀伤细胞)的有丝分裂及其活性,进而影响它们相关的细胞因子(如白介素,肿瘤坏死因数-α和干扰素)表达.有证据表明:从药用真菌分离得到的β-D-葡聚糖是通过与免疫效应细胞膜上的3型补体受体(CR3,αmβ2整联蛋白,或CD11b/CD18)结合,进而诱发生物反应.这种配体受体复合物被摄入细胞后,引发一系列分子事件(如核因子NF-κB的活化),同时我们也观察到了灵芝提取成分具有一定免疫抑制作用.灵芝所表现出的抗癌,抗炎症等疗效都与其免疫调节作用有关.然而,其分子机理还有待进一步的研究.
其他文献
Human Tidl is a human homolog of bacterial DnaJ and the Drosophila tumor suppressor Tid56 that have two alternatively spliced isoforms Tid-Long and Tid-Short (T
Renal cell carcinoma (RCC) is the most common epithelial malignancy of the kidney in adults and accounts for approximately 3％ of adult malignancies and represent
Mitochondria play a primary role in cellular bioenergetics in mosteukaryotic cells, which are responsible for producing nearly 95％ of cellular ATP through mitoch
Protein quality control in mitochondria is essential for proper protein homeostasis, which maintains the mitochondrial function well and prevents the proteotoxi
Mitochondriai transcription factor A (TFAM), a member of high-mobility group (HMG) protein family encoded by the nuclear genome and transported into the mitocho
Biogas generated from anaerobic digestion (AD) systems is a renewable source of methane,but difficult to store and transport due to its gaseous form at ambient
The 6-hydroxydopamine (6-OHDA)-induced rat model is widely used to evaluate nigrostriatal dopamine neuronal degeneration.The purpose of this study was to invest
哺乳动物不育系20样激酶1/2(mammalian sterile 20-like kinase1/2,MST1/2)是哺乳动物中Hippo信号通路的核心成员,具有调节器官大小、细胞增殖、凋亡及抑制肿瘤生长等功能.近
DKK1 is known as antagonist of the canonical Wnt signalling pathway.It can block canonical Wnt signaling by combining with Kremen and Lrp6 transmembrane recepto
从药用真菌中鉴定出安全、有效的成分来预防和治疗癌症受到了越来越多的关注.灵芝作为一种药用真菌,单用或联合其他药物(草药或化学合成药)时,都表现出令人满意的效果.灵芝多