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Renal cell carcinoma (RCC) is the most common epithelial malignancy of the kidney in adults and accounts for approximately 3％ of adult malignancies and represents 90-95％ of renal neoplasms in western countries.RCC is also a fundamentally metabolic disease.Among all type of RCC, the most common histological subtype is the clear cell renal cell carcinoma (ccRCC) which accounts for 70-80％ of all RCC.In several types of human cancer, gene and protein expression studies have demonstrated to be very useful for classifying tumors and identifying unique molecular biomarkers.Until today, there is no reliable diagnostic and prognostic biomarker for ccRCC, though a constant effort has been made in the searching of candidates of ccRCC biomarkers.