Sphingosine kinases(Sphks) are the rate-limiting kinases in the generation ofsphingosine-1-phosphate,which is a well-established intracellular pro-survival lipidmediator.
Objective To investigate the effects of hippocampal neurons autophagy and endoplasmic reticulum stress(ERS)on the memory function of mice after focal cerebral ischemia-reperfusion(I-R),and the possibl
Objective: Electro-acupuncture(EA)is a novel therapy based on combining traditional acupuncture with modern electrotherapy,and is currently being investigated as a treatment for ischemic stroke.
Objective Neural stem cell(NSC)replacement promises a novel therapeutic strategy for stroke and other brain diseases.However,this approach is impeded possibly due to the hostile brain environments whi
Objective Chronic cerebral ischemia is a serious threat to human health.Recent studies indicate particular miRNA changes in response to ischemia/hypoxia brain damage.
Glibenclamide(GBC)confers neuroprotection in animal models as well as retrospective clinical studies.This study determines whether GBC improves outcome after cardiac arrest in rats.
The present study was designed to reveal the potential role of let-7c-5p,a highly conserved miRNA in stroke.We found that the content of let-7c-5p was significantly decreased in the plasma of patients
Columnar restriction is commonly observed in vertebrates and invertebrate nerve system,which helps to form non-overlapping receptive fields and preserve the spatial sensory information from the periph
Zinc finger E-box binding homeobox 1(Zeb1)is a key regulator of epithelial-mesenchymal transition(EMT),which is critical for invasion and metastasis of carcinoma cells,as well as embryonic development
The transcription factor nuclear factor erythroid-2-related factor 2(Nrf2)and its target heme oxygenase-1(HO-1)play critical role in the anti-oxidative defense against different kinds of toxic insults