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Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-7 Some dually and multiply stimuli-sensitive copolymers have been synthesized and self-assembled into functional aggregates with great potential in smart release systems,in which various internal and external stimuli have been applied to induce the dissociation or morphology changes of copolymer aggregates and accelerate the release process.