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CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against foreign DNA or RNA.The CRISPR-associated protein (Cas) system is a powerful tool for genome editing in numerous organisms.And the Cas protein plays a critical role to bind guide DNA and cleavage target DNA or RNA in the entire biological process.However,there is no classifier available to predict the Cas protein until now.