【摘 要】
：
The specific and robust effect of RNA interference on gene expression renders small interfering RNA(siRNA)a valuable therapeutic agent for the treatment of cancer and neurodegenerative disorders.Howev
【机 构】
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National Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
The specific and robust effect of RNA interference on gene expression renders small interfering RNA(siRNA)a valuable therapeutic agent for the treatment of cancer and neurodegenerative disorders.However,the instrisic deficiencies of siRNA,such as short plasma half-life,poor membrane penetrability and lack of target ability,have seriously reduced their therapeutic efficiency.To overcome those drawbacks,several siRNA delivery strategies have been proposed in our laboratory.
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