The influence of the signal-transduction pathways on differentiation of mesencephalic neural stem ce

• 作 者: Yan-YongWANG[1]PingGU[1]YaWEN[1]Qin-YingMA[1]KunWANG[1]Ming-WeiWANG[1]Dong-ShengCUI[2]YuanGENG[2]LiLIU[2]
• 机 构: Department of Neurology, First Hospital of Hebei Medical University, Shijiazhuang, 050031, China
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　The cytokines and growth factors excreted by bone marrow stromal cells (BMSCs) consist the microenvironment for hematopoiesis,and also regulate central and peripheral nervous system.The dissolvable molecules excreted by BMSCs play a key role in inducing the Neural Stem cells (NSCs) differentiate into high proportional neurons.The morphogenesis and differentiation of neurons and glial cells could be induced by cell signals such as neurotransmitter,neurotrophic factors and growth factors through different signal-transduction pathways.Extracellular signal-regulated kinases (ERK1/2),038 Mitogen activated protein kinases (MAPKs) and c-Jun N-terminal protein kinase (JNK) are three main signal-transduction pathways in eukaryotic cells and was generally expressed in central nervous system (CNS).