【摘 要】
：
Compelling evidences indicate a key role for regulatory T cells (Tregs) on the host response to cancer and recent studies indicated that the generation of effective WTl-specific cytotoxic T cells can
【机 构】
：
Tumor Immunology Lab,Research Center SCT Program King Faisal Specialist Hospital & Research Center K
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Compelling evidences indicate a key role for regulatory T cells (Tregs) on the host response to cancer and recent studies indicated that the generation of effective WTl-specific cytotoxic T cells can be largely affected by the presence of Tregs.This is the first study to describe human Tregs generated specifically against the WT1 antigen which is overexpressed in several human leukemias and provide the mechanism by which these anti-WTl Tregs inhibit the immune response in leukemia patients.We have generated T cell lines and clones that specifically recognized a WT1-84 peptide in an HLA DRB 1 *0402/TCR-Vβ8-restricted manner.Importantly, they recognized HLA-DRBl*04-matched fresh leukemic cells expressing the WT1 antigen.These clones exerted a Th2 cytokine profile, had a CD4+CD25+Foxp3+GITR+CD127-Tregs phenotype, and significantly inhibited the proliferative activity of allogeneic T cells independently of cell-contact or cytokine production.
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