【摘 要】
：
With current treatment protocols more than 85% of adults with acute lymphoblastic leukemia (ALL) achieve complete remission (CR), however, approximately halfofCR patients subsequently relapse, which i
【机 构】
：
Department of Hematology and Bone Marrow Transplantation Silesian Medical University in Katowice Pol
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
With current treatment protocols more than 85% of adults with acute lymphoblastic leukemia (ALL) achieve complete remission (CR), however, approximately halfofCR patients subsequently relapse, which is unequivocally associated with poor prognosis.The major task is to identify high-risk patients who require intensified post-remission therapy as well as to apply new drugs targeting molecular and phenotypic features characterizing particular subtypes of the disease.Conventional criteria for high-risk ALL include initial tumor burden (WBC >30 x109/L for B-lineage ALL), higher age, adverse immunophenotype (pro-B, early-T, mature-T), late CR achievement, and adverse karyotype (t(9;22), t(4;11)).
其他文献
This study was supported by a grant from the State Committee for Scientific Research, Polish Ministry for Scientific Research and Information Technology, no 1423/P01/2007/32, 2007-2010 An accumulating
Prostate cancer is one of the most prevalent cancers and the second leading cause of cancer-related death in men in Western countries.Hormone refractory prostate cancer (HRPC) is an end stage disease
Hsp70 is known to constitute the ubiquitous cellular protective mechanism whose efficacy was proved in a great number of studies in vitro and in vivo.In cancer cells Hsp70-mediated protection is mainl
Breast cancer is a common but biologically diverse group of malignancy, with considerable heterogeneity in behavior, outcome and response to therapy.Recent gene expression profile studies have led to
Skeletal metastasis is a major complication of advanced breast cancer which results in bone fractures and considerable pain burden.Tumor cells arriving at bone metastatic sites disrupt the balance bet
The c-Jun NH2-terminal kinases (JNKs) are members of the mitogen-activated protein kinase family and active several transcription factors, including p53, c-Jun and activating-protein 1.Thus, the JNK s
Recurrence of carcinomas due to cells that migrate away from the primary tumor is a major problem in cancer treatment and a cause of cancer recurrence.Fascin is an actin-bundling protein that is low o
Proton magnetic resonance imaging (MRI), with or without contrast enhancement, has emerged in recent years as the preferred noninvasive neuroimaging modality for clinical evaluation and monitoring the
Brain tumors are now the leading cause of cancer-related deaths in children under age 15.Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches are desperately nee
The molecular signature of chronic myeloid leukemia (CML) is the BCR-ABL fusion gene originating in a pluripotent hematopoietic stem cell.The BCR-ABL oncoprotein (p210BCR-ABL) has constitutively eleva