【摘 要】
：
Objectives Intermittent high glucose, one general and important phenomenon existed in patients with diabetes, has greater effect than sustained high glucose on development of diabetic cardiovascular c
【机 构】
：
Department of Endocrinology,Shandong Provincial Qianfoshan Hospital,Shandong University,No.66 Jingsh
【出 处】
：
中华医学会第十二次全国内分泌学学术会议
论文部分内容阅读
Objectives Intermittent high glucose, one general and important phenomenon existed in patients with diabetes, has greater effect than sustained high glucose on development of diabetic cardiovascular complications, in which endothelial dysfunction caused by oxidative stress is regarded as the initiation of these pathophysiology.However, at present, no data are available neither on the degree of endothelial oxidative DNA damage caused by intermittent high glucose nor on the potential protective role of antioxidants.Ginkgo biloba extract (EGb) 761, an antioxidant herbal medicine, has commonly been used as a therapeutic agent for cardiovascular and neurological disorders.The aim of this study was to investigate oxidative DNA damage of endothelial cells under the pro-atherosclerotic stressor intermittent high glucose and the potential protective role of EGb761 in vitro.
其他文献
Objective This study aimed to investigate the association of CCR2 and GPR177 polymorphisms with bone mineral density in elderly men of Chinese Han population.Methods BMD of the proximal femur (femoral
Aim The present studies often on type 2 diabetes mellitus and AD related research, this paper is to evaluate the cognitive function of the patients with type 2 diabetes who did not complain about cogn
Objective To determine the prevalence of microalbuminuria and the relationships with the components of metabolic syndrome.Methods The subjects in this cross-sectional study were individuals 20-79 year
Aims 1.This study intends to use methylation gene chip in macrovascular complications in diabetic patients, genetic diagnosis target in view of early diagnosis to find out a better table for diabetic
BACKGROUND Epidemiological and clinical evidence suggests that diabetes may be associated with the occurrence and prognosis of many types of cancer.However, the relationships between diabetes and meta
Background Glibenclamide has a newly discovered role in inflammation regulation besides its anti-diabetic effect.As an ATP-sensitive potassium (KATP)channel inhibitor, glibenclamide also antagonizes t
Objective MeCune-Albright syndrome (MAS) is a sporadic, postzygotic disease presenting with potyostotic/monoostotic fibrous dysplasia(FD), cafe-au-lait spots and multiple endocrinopathies.It is caused
Aim Metabolic memory of hyperglycemia has been widely reported in diabetic cardiovascular complications.Oxidative stress is the major pathway involved in the development of diabetic vascular complicat
To compare the therapeutic effects of epalrestat and mecobalamine on diabetic peripheral neuropathy(DPN).We treated48 patients in DPN with Epalrestat and 42 with mecobalamine in this study.Blood sugar
Background The brown adipose tissue (BAT) produces nonshivering thermogenesis and plays important role in energy expenditure, its function is mainly modulated by β-adrenergic and thyroid hormone signa