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Objective MeCune-Albright syndrome (MAS) is a sporadic, postzygotic disease presenting with potyostotic/monoostotic fibrous dysplasia(FD), cafe-au-lait spots and multiple endocrinopathies.It is caused by an acting mutation in the GNAS 1 gene encoding the alpha chain of the heterotrimeric G protein(Gsa).Growth hormone(GH) excess is an uncommon but severe complication of MAS.We conducted this study to describe clinical manifestation of GH excess in the context of MAS, and analyze these patients responses to treatments.