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Aim Metabolic memory of hyperglycemia has been widely reported in diabetic cardiovascular complications.Oxidative stress is the major pathway involved in the development of diabetic vascular complications, while dysfunctional endothelial nitric oxide synthase (eNOS) is considered as an important source of ROS.Furthermore, Epigenetic changes are implicated in the formation of metabolic memory of hyperglycemia.The present study investigated whether oxidative stress derived from dysfunctional eNOS is involved in metabolic memory as well as whether epigenetic changes in eNOS gene has happened in metabolic memory.