Radical enhanced radiotherapy with active hypoxia targeting tumor microenvironment responsive nano-c

• 作 者: Chao Zhang Da Huo Yong Hu
• 机 构: Institute of Materials Engineering,National Laboratory of Solid State Microstructure,Collaborative I
• 出 处: 中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
• 发表日期: 2016年5期
• 关键词: Nanoparticles Hypoxia targeting Radiotherapy Radiosensitization Photothermal

　　Conquering the hypoxia induced resistance to clinical routine treatments like chemotherapy and radiotherapy is of great therapeutic significance and remains challenging.Although,nanomedicine has been used to alleviate the hypoxic degree in tumor,it is still hard to design a satisfactory long-circulating platform,which also effectively targets the hypoxic lesion in deep tumor.In this study,we reported a versatile nano-cluster bomb,which could actively target the hypoxia microenvironment of tumor with long half-life in blood.