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Preeclampsia is a pregnancy-related syndrome which can cause perinatal mortality and morbidity.Inadequate invasion by trophoblast cells may lead to poor perfusion of the placenta,even result in preeclampsia.Understanding the molecular mechanisms underlying placentation facilitates the better intervention of preeclampsia.Urokinase-type plasminogen activator receptor (uPAR) is involved in the physiological and pathological processes.Leukemia inhibitory factor (LIF) is an important regulator in the establishment of pregnancy.However,the expression of uPAR in preeclamptic patients and its relationship with LIF remains unclear.In current study,we found that the level of uPAR was relatively lower in the placentas form preeclamptic patients as compared with normal pregnant women.