【摘 要】
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Neuroinflammation characterized by increased activation of glial cells,immune cells infiltration and inflammatory cytokines release,is the common pathologic
【机 构】
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DalianMedicalUniversityDepartmentofAnatomy
【出 处】
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第六届中国细胞生物学学会HIPPO年会暨大连医科大学2016年生命科学学术交流会
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Neuroinflammation characterized by increased activation of glial cells,immune cells infiltration and inflammatory cytokines release,is the common pathological feature of diseases in the central nervous system(CNS).Microglia(MG) as antigen-presenting and innate immune cells in the CNS plays an important role in neuroinflammation by polarized into M1 and M2 phenotypes which have very different morphology and functions.Cathepsin C(Cat C) belongs to papain hydrolase supper family and has been found involved in peripheral inflammatory disease by which regulates the activation of serine proteases in T cells,natural killer cells,neutrophils and mast cells,but the functional role of Cat C in the CNS neuroinflammation is unclear.In present study,we used microglial Cat C conditional knock down(KD) and overexpression (OE) mice to create neuroinflammatory animal model by LPS intraperitoneal or intraventricular injection.
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