Background The efficacy and safety of olanzapine monotherapy are evaluated in Japanese patients from a larger,global study of bipolar depression.
Objectives Mammalian target ofrapamycin (mTOR) is a protein kinase involved in the regulation of translation initiation and protein synthesis required for synaptic plasticity.Recent studies suggest th
目的 研究布南色林片单次给药后的人体药代动力学.方法 经广州市脑科医院伦理委员会审批通过,招募30例健康志愿者并分为3组,每组10人,男女各半,分别单次口服4 mg、8 mg和12 mg布南色林片后,采集0、0.25、0.5、0.75、1、1.5、2、3、4、6、8、12、24、36、48和60 h内动态血标本,采用HPLC-MS/MS测定血浆中布南色林的浓度,最后用DAS 3.2.4软件对试验数
目的 探讨精神分裂症患者智力和记忆、持续注意、执行功能之间的关系,以便更加准确的理解精神分裂症患者智力的真实情况.方法 选取符合国际疾病分类标准第十版(ICD-10)之相应诊断标准的住院精神分裂症患者120例(男56例,女64例,平均年龄(35.91±12.02)岁;平均发病年龄(26.46±7.59)岁;平均病程(9.29±9.47)年;平均受教育年限(13.04±3.01)年)及60例健康正常
Objective Mirtazapine,an antagonist for central α2-adrenergic autoreceptors and heteroreceptors,and postsynaptic 5-hydroxytryptamine2 (5-HT2) and 5-HT3 receptors,achieves its unique therapeutic effect
Objectives Recent studies have demonstrated that antidepressant effect of N-Methyl-D-aspartate (NMDA) antagonist ketamine activates rapidly the mammalian target of rapamycin (mTOR) pathway and increas
Objective Accumulating evidence from human genetic and animal model studies implicates the pituitary adenylate cyclase-activating polypeptide (PACAP) signaling pathway as a risk factor for psychiatric
Objective Cognitive deficits are a fundamental feature of the psychopathology of schizophrenia.Abundant evidence supports atypical antipsychotic medications such as olanzapine can improve the neurocog
Objective Population pharmacokinetics can predict antipsychotic plasma concentration at a given time point prior to an actual dosage change.This in turn can be used to estimate a corresponding dopamin
Objective Many neuroimaging studies found that the gender had a varying degree relationship with structural and functional brain imaging in depressed patients.To explore energy feature of the spontane