【摘 要】
：
Cutaneumcarcinoma is commonly responsible for significant morbidity and mortality and the treatments have not progressed significantly in the last few years.Alternative strategies such as chemoprevent
【机 构】
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南京中医药大学药学院药理系,中国南京,210023;南京中医药大学药学院江苏省中药药效与安全性评价中心,中国南京,210023
【出 处】
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2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议
论文部分内容阅读
Cutaneumcarcinoma is commonly responsible for significant morbidity and mortality and the treatments have not progressed significantly in the last few years.Alternative strategies such as chemoprevention are being considered.Here we investigated the chemomodulatory potential of lycopene against 9, 10-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-inducedskin carcinogenesis in female ICR mice and TPA-induced malignant transformation of JB6 P+ cell.In vivo,pretreatments with lycopene at different doses significantly delayed tumor formation and growth.These treatments also extraordinary reduced the tumor incidence and tumor volume.
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