【摘 要】
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Introduction We have recently found Diallyl Trisulfide(DATS), a natural product of garlic,which has shown anti-cancer metastasis activity.We investigated its efficacy and mechanism of action in the tr
【机 构】
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南京中医药大学药学院药理教研室 南京中医药大学药学院药理教研室;江苏省中药药效与安全性评价重点实验
【出 处】
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2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议
论文部分内容阅读
Introduction We have recently found Diallyl Trisulfide(DATS), a natural product of garlic,which has shown anti-cancer metastasis activity.We investigated its efficacy and mechanism of action in the treatment of triple-negtive breast cancer in preclinical models.Methods We evaluated the anti-breast-cancer migration and invasion efficacy of DATS in human triple-negative, i.e., estrogen receptor-negative, progesterone receptor-negative and HER2-negative (MDA-MB231、 HS 578T) breast cancer cell lines the most difficult-to-treat (triple-negative) subtypes of breast cancer-and their metastasis model in nude mice.
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