【摘 要】
：
Objective: To conducte a phase Ⅰ study to determine the toxicity, tolerated dose, and clinical feasibility of nimotuzumab in combination with concurrent chemoradiotherapy for Chinese malignant glioma
【机 构】
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Beijing Shijitan Hospital affiliated to Capital Medical University,Beijing,China
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: To conducte a phase Ⅰ study to determine the toxicity, tolerated dose, and clinical feasibility of nimotuzumab in combination with concurrent chemoradiotherapy for Chinese malignant glioma (MG) patients after surgical resection.Methods: Patients with pathologically proven grade 3 and grade 4 gliomas were enrolled in this study.Protocol included nimotuzumab infusions plus standard Stupp schedule (postoperative radiotherapy with a total dose of 60 Gy, in combination with daily temozolomide).Patients received six weekly nimotuzumab infusions at three levels (i.e., 100, 200, and 400mg/week).If none of the first three patients enrolled at a dose level experienced dose-limiting toxicity (DLT), then the dose was escalated appropriately.If DLT was observed, then another three patients were added to that dose level.
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