P-glycoprotein associates with Anxa2 and promotes migration and invasiveness of multidrug-resistant

来源 :22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会) | 被引量 : 0次 | 上传用户:asfdasdfasd
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Objective: Multidrug resistance (MDR) and metastasis are the major causes of treatment failure and death among cancer patients.Several studies have demonstrated that the acquisition of the MDR phenotype was associated with an elevated cancer cell invasion and metastasis.In addition, increasing evidences have shown that multidrug transporter proteins might have other important functions in cancer progression independently of cytotoxic drug efflux; however, the detailed mechanism remains unclear.Our previous studies have shown that Anxa2was up regulated in MDR breast cancer cells, and Anxa2 or P-glycoprotein downregulation by small interfering RNA was inhibited.
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