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Every cell is decorated with a dense layer of glycans,whose structures and patterns vary in different cell types and tissues.Specific labeling and visualization of glycans,which is crucial for elucidating the biological functions of glycosylation,presents a significant challenge for analytical chemists.We are interested in developing chemical methods for addressing this challenge.Herein,we present a liposome-assisted chemical reporter strategy for cell-selective and tissue-specific imaging of glycosylation in vivo.Further,a FRET-based strategy has been developed to specifically visualize the glycosylation state of a protein of interest in live cells.These chemical tools have facilitated our studies on the dynamic changes of glycosylation in important physiological and pathological processes.