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It was demonstrated 15th years ago that thymic stromal lymphopoietin(TSLP),a IL-7–like cytokine produced by epithelial cells,could strongly activate human myeloid dendritic cells to induce an inflammatory TH2 response characterized by high TNF-α and little IL-10 production,distinct from the regulatory TH2 responses characterized by low TNF-α and high IL-10 production.