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Synergistic effect of Cyanex 302 on extraction of zinc and manganese with D2EHPA in sulfate media was investigated.Experiments were carried out in the pH range of 1.0-5.0, temperature of 40 ℃C with sole D2EHPA and Cyanex 302 as extractant and D2EHPA to Cyanex 302 ratios of 1/3,1/1 and 3/1.The experimental results showed that the co-extraction of zinc and manganese increased with increasing equilibrium pH and temperature.Increasing the D2EHPA to Cyanex 302 ratio in the organic phase, caused a left shifting of extraction isotherm of zinc and right shifting of extraction isotherm of manganese.