地中海富盐菌乙酰化修饰研究

来源 :第七届全国微生物遗传学学术研讨会 | 被引量 : 0次 | 上传用户:aaxiongaa
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  蛋白质翻译后修饰,是细胞调节自身生理生化功能的一种重要手段。迄今,已知的翻译后修饰有400多种。乙酰化分为两类:N-末端α位的乙酰化修饰和内部ε位的赖氨酸乙酰化修饰,前者为不可逆修饰,后者是一种可逆修饰,在细胞的生命活动中发挥着重要的作用。
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聚羟基丁酸羟基戊酸酯(PHBHV)是微生物在营养不平衡下合成的一种胞内聚酯。本文以前期利用地中海富盐菌合成的PHBHV为材料,对其进行了生物可降解性和相容性的研究。将材料置于模拟体液中降解240天,PHBHV重量和单体比例没有明显变化。而当材料植入兔子皮下,3个月后材料具有轻微的质量损失,6个月后质量损失严重,特别是O-PHBHV-1(高规共聚)的质量仅为植入前的15%。