Follistatin-like 1 is a critical regulator of lung fibrosis

• 作 者: YingyingDong[1]WenNing[2]LongQiao[3]YanGeng[1]HuixiaGeng[3]JingxiaSun[1]XiuhongYang[2]LianLi[2]XueLi[2]GengyanBai[2]
• 机 构: Model Animal Research Center, Nanjing University, Nanjing, 210061 PR China
• 出 处: 中国细胞生物学学会全体会员代表大会暨第十二次学术大会
• 发表日期: 2011年期

　　Idiopathic pulmonary fibrosis ([PF) is a chronic, progressive, and often fatal lung disease of unknown etiology, characterized by (myo)fibroblasts accumulation and extracellular matrix (ECM) deposition.Fstl1 (follistatin-like1), an inducible extracellular glycoprotein by transforming growth factor β1 (TGF-β1), has been observed increased expression in lung tissues from IPF patients compared with controls by rnicroarray analysis.