The adaptor function of Trs20 in mammalian TRAPPs explains Trs20-associated SEDT and Trs120-associat

• 作 者: Xing-gangWu;MinZong;SidneyYu;
• 机 构: School of Biomedical Sciences and 2Epithelial Cell Biology Research Center,The Chinese University of
• 出 处: 中国细胞生物学学会全体会员代表大会暨第十二次学术大会
• 发表日期: 2011年期

　　The TRAPP (Transport protein partiele) complex is a conserved protein complex functioning at various steps in vesicle transport.Although yeast has three functionally and structurally distinct forms,TRAPPI, Ⅱ and Ⅲ, emerging evidence suggests that mammalian TRAPP complex may be different.Mutations in the Trs20 subunit cause X-linked spondyloepiphyseal dysplasia tarda, while mutations in the Trs120 subunit cause postnatal mental retardation with microcephaly.