Development of a Novel Anti-diabetes Agent

来源 :中国上海第七届国际新药发明科技年会 | 被引量 : 0次 | 上传用户：david_test

【摘要】

：

【作者】

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Moon K.Song

【机构】

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UCLA School of Medicine and VA Greater Los Angeles Healthcare System USA

【出处】

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中国上海第七届国际新药发明科技年会

【发表日期】

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2009年1期

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　　1.Discovery of a new drug that treat insulin resistance,which is not a simple blood glucose lowering drug:We have discovered that Cyclo (his-pro) (CHP),a thyrotropin releasing hormone metabolite,stimulated intestinal zinc absorption and muscle cell zinc uptake.CHP plus zinc (Cyclo-Z) treatment significantly enhanced glucose uptake in muscle cells.Cyclo-Z treatment also increased insulin degrading enzyme (IDE) synthesis in human amyloid protein transgenic mice.Stimulation of IDE synthesis is the mechanism by which Cyclo-Z ameliorates diabetes.

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