【摘 要】
：
Cancer is a complex disease resulting from perturbations in multiple regulatory intracellular systems leading to an overall increase in cell number and thus tumor formation.As cancer is a multifactori
【机 构】
：
Department of Medicinal Chemistry University of Minnesota USA
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Cancer is a complex disease resulting from perturbations in multiple regulatory intracellular systems leading to an overall increase in cell number and thus tumor formation.As cancer is a multifactorial process involving the expression of a large number of proteins,a single molecule which could simultaneously modulate more than one pathway or target involved in cancer would have a significant advantage over the current strategies for combination therapy.NF-κB and AP-1 are two important transcription factors for many cell types and are thought to be promising targets for the development of anti-cancer therapeutics.It has been well documented that NF-κB and AP-1 pathways play an important role in promoting metastases,tumor progression,angiogenesis and chemoresistance.A variety of genes involved in cancer are regulated by the combined action of NF-κB and AP-1.Therefore,the modulation of these transcriptional factors may provide us with efficient tool for the treatment of cancer.
其他文献
Background During the past 10 years there has been growing interest in the role of mitochondrial dysfunction in many diseases,including heart disease,metabolic disorders,neurological diseases,and nutr
A large amount of experimental data on the effects of the nonsteroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-1,2 (COX-1,2) have revealed a significant variability in IC50 and COX-1/COX-2
Drug transporters are membrane proteins involved in the uptake or efflux of drugs by several tissues such as the intestine,liver,kidney and brain.They can have a significant impact on the pharmacokine
Tremorgenic neuromycotoxicosis caused by extrolites from several Penicillium species (e.g.Penicillium crustosum) is an important syndrome in domestic animals.The potential hazard to humans remains unc
Cell lines are renewable and constitute an invaluable resource of central nervous system cell types for studies of news therapeutical agents against diseases of CNS.We have determined that flavonoids
For over three decades,controlled drug delivery by magnetic force,as exemplified by magnetic nanoparticles,has been of great interest,simply because it is relatively easy to apply a magnetic force ext
The main goal of the cancer research is to improve the clinical outcome of cancer patients.At present,we can perform tailor-made chemotherapy,the selection of effective chemotherapy based on evaluatio
CDC25 phosphatases are key actors in cyclin-dependent kinases activation whose role is essential at various stages of the cell cycle.CDC25 expression is upregulated in a number of human cancers.CDC25
Cigarette smoking is a major cause of lung cancer; however,it has been difficult to reproduce the tumorigenicity of cigarette smoke in preclinical animal models.Increased lung tumorigenicity has previ
Molecular targets for anti-cancer drugs have emerged from the accumulated evidence obtained by a huge number of the studies in oncology during more than recent three decades.These molecular-targeted a