【摘 要】
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Mitochondria-targeted black phosphorus(BP)nanomaterials are expected to achieve enhanced photothermal antitumor effects since mitochondria are more sensitive to hyperthermia1 and BP excellent optical
【机 构】
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School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University,Guangzhou 510275
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Mitochondria-targeted black phosphorus(BP)nanomaterials are expected to achieve enhanced photothermal antitumor effects since mitochondria are more sensitive to hyperthermia1 and BP excellent optical properties2.However,there are several challenges to overcome before offering real benefits,such as poor stability,poor dispersibility,and difficulty in achieving a real mitochondria targeting.Here,a “three-in-one” mitochondria-targeted BP nanoplatform,called as BPQD-PEG-TPP,was designed.In this nanoplatform,BP quantum dots(BPQDs)were covalently modified with a heterobifunctional PEG,in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine(TPP)group.Besides of its excellent near-infrared photothermal properties,BPQD-PEG-TPP had good dispersibility and much enhanced stability under physiological conditions,efficiently targeted mitochondria and promoted ROS production through a photothermal effect.The combination of targeting mitochondria and PTT resulted in an excellent ability to inhibit tumor cell growth both in vitro and in vivo.Thus this “three-in-one” BP nanoplatform with enhanced photothermal efficacy and negligible toxicity on healthy tissues might be a promising strategy for mitochondria-targeted photothermal cancer therapy.
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