【摘 要】
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Background: Genome-wide association studies (GWAS) have been extremely successful in finding genetic loci underlying human inheritable disorders.In the past
【出 处】
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第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
论文部分内容阅读
Background: Genome-wide association studies (GWAS) have been extremely successful in finding genetic loci underlying human inheritable disorders.In the past 10 years, more than 13,000 susceptible loci have been reported in almost 2,000publications.Unfortunately, only a handful of these loci have been mapped to specific functional variants that deliver insight into the mechanisms of these disorders.In this study, we demonstrate a fine-mapping strategy that refines these large and ambiguous GWAS loci to small high quality subsets that contain the causal and functional variants.
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