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  5. Binning Strategy and Parallel Computation Method to Detect Copy Number Variations in Cancer Genes

Binning Strategy and Parallel Computation Method to Detect Copy Number Variations in Cancer Genes

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：sadsorry11
【摘 要】
：
　　Background: Studies show that cancer may result from somatic alterations in related genes, including point mutation, copy number variations and structural r
【作 者】
：
刘绍颉 朱小谦 邹丹 陈钢 彭绍亮 
【机 构】
：
计算机学院,国防科技大学,长沙,410073华大基因,深圳,518083
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年10期
【关键词】
：
CNVs Detection Binning Strategy Segmentation Parallel Computation 
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　　Background: Studies show that cancer may result from somatic alterations in related genes, including point mutation, copy number variations and structural rearrangements.Its a powerful way to detect tumor gene copy number variations (including gains and losses) in studies when discovering cancer-causing genes.The developing high-throughput sequencing technology produces mass of data, which not only promotes the algorithm when detecting copy number variations, but also shows great challenges in the efficiency during the data processing.
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