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OBJECTIVE:The crosstalk between mTORC1/S6K1 signaling and AMPK is emerging as a powerful andhighly regulated way to gauge cellular energy and nutrient content.The aim of the current study was toelucidate the mechanism by which exercise training reverses lipid-induced insulin resistance and the roleof AMPK/mTOR/S6K1 signaling axis in mediating this response in skeletal muscle.